Cholesterol 7-alpha-Hydroxylase

A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.

Also Known As:

Cholesterol 7 alpha Hydroxylase; CYP7; CYP 7; CYP 7A; Cholesterol 7-alpha-Monooxygenase; Cholesterol 7alpha-Hydroxylase; Cholesterol-7-Hydroxylase; Cytochrome P450 7; Cholesterol 7 Hydroxylase; Cholesterol 7 alpha Monooxygenase; Cholesterol 7alpha Hydroxylase; Cytochrome P 450 CYP7; CYP7A; Cytochrome P-450 CYP7; Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Cholesterol 7-alpha-Hydroxylase: 138
        Cytochrome P450 Family 7: 8
        Cholesterol 7-alpha-Hydroxylase: 138
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Steroid Hydroxylases: 11
      - Cholesterol 7-alpha-Hydroxylase: 138
    - Cytochrome P450 Family 7: 8
      - Cholesterol 7-alpha-Hydroxylase: 138
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Cholesterol 7-alpha-Hydroxylase: 138
        Cytochrome P450 Family 7: 8
        Cholesterol 7-alpha-Hydroxylase: 138

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